HPE ProLiant AMD Servers
HPE ProLiant servers with AMD EPYC™ processors deliver enterprise-grade security, energy-efficient performance, and AI-ready scalability for hybrid and data-intensive workloads.
We get it. IT never sleeps.
Every day, your infrastructure faces new demands. Security threats evolve, workloads expand, and your team is expected to do more with less. Here’s what we hear from IT leaders like you:
Vulnerabilities
From firmware to the cloud, every layer needs protection. One breach can compromise data, trust, and uptime — so defense has to start at the silicon level and extend across your stack.
Visibility gaps
With sprawling hybrid environments, it’s tough to see what’s really happening. Energy use, resource consumption, and system health often live in disconnected dashboards.
Evolving workloads
AI, edge, and virtualization are reshaping compute needs faster than traditional infrastructure can adapt. You need flexibility and performance — without complexity.
Inefficiency
Power costs rise while staff resources shrink. Running at full throttle 24/7 isn’t sustainable for budgets or teams.
We’ll help you modernize without disruption — defend data, simplify management, and free your team to innovate.
What You Gain with AMD-powered HPE Servers
HPE ProLiant AMD servers deliver energy-efficient compute, robust security, and AI-ready infrastructure for hybrid cloud and data-driven workloads.
Performance & Security Highlights:
5th Gen AMD EPYC processors deliver up to 41% more performance per watt vs. Gen10 systems. Customers achieve up to 68% less power consumption, 87% fewer servers, and 67% lower 3-year TCO for key workloads.
Up to 35% performance gain vs. Gen11 for select workloads. HPE Silicon Root of Trust and AMD Infinity Guard extend multi-layer security from hardware to firmware.
Azure Local Integration
HPE ProLiant AMD EPYC servers are validated and optimized for Microsoft Azure Local. Run Azure-consistent services on-premises, maintain data sovereignty and low latency, and manage hybrid operations easily with Azure Arc and HPE Compute Ops Management (COM).
Deployment Options
Integrated Systems for Azure Local — Turnkey, appliance-like systems with annual OS refreshes and factory integration for seamless setup.
Validated Nodes for Azure Local — Flexible configurations supporting reuse of existing hardware and easy infrastructure integration.
Select Your Solution
HPE ProLiant DL145 Gen11: Edge AI-Ready Server
Purpose-built for the edge, the DL145 Gen11 delivers secure, energy-efficient compute for AI, retail, and industrial workloads—wherever you need it most.
- Processor: AMD EPYC™ 8004 Series, 8–64 cores
- Operating Range: –5 °C to 55 °C
- Virtualization: Up to 128 VMs / 480 containers
- Chassis: Wall-mountable 15″×16″, near-silent operation
- GPU: Single or double GPU support, front access
- Management: HPE iLO 6 + Compute Ops Management (COM) for low-touch setup
- Resilience: Dust and shock tolerance for harsh edge environments
HPE ProLiant DL325 Gen11: Virtualization Powerhouse
A low-cost 1U single-socket solution that delivers exceptional value balancing compute, memory, and network bandwidth at single-processor economics.
- Processor: AMD EPYC™ 9004 & 9005 Series, up to 160 cores at 400W
- Memory: Up to 3 TB DDR5 at 6400 MT/s, 12 DIMM channels
- Expansion: PCIe Gen5 I/O with up to 2x16 PCIe Gen5 slots, 2 OCP 3.0 slots
- Storage: EDSFF E3.S drives, hot-pluggable M.2 RAID boot options
- GPU Support: Up to two GPUs at the front
- Management: HPE iLO 6 + Compute Ops Management
- Security: Silicon Root of Trust + AMD Secure Processor
HPE ProLiant DL345 Gen11: Storage-Dense Virtualization
A single-socket 2U server built for large-capacity, storage-dense virtualization and software-defined storage workloads.
- Processor: AMD EPYC™ 9004 Series, up to 128 cores at 400W
- Memory: Up to 3 TB DDR5 at 4800 MT/s, 12 DIMM channels
- Storage: Up to 20 LFF / 34 SFF / 36 EDSFF E3.S NVMe drives
- Expansion: PCIe Gen5, up to 6x16 PCIe Gen5 slots, 2 OCP 3.0 slots
- GPU Support: Up to four GPUs, front-accessible
- Management: HPE iLO 6 + Compute Ops Management
HPE ProLiant DL365 Gen11: Compute-Dense Performance
A dense, dual-socket 1U server engineered for high-performance, compute-intensive workloads like VDI, EDA, and CAD.
- Processor: AMD EPYC™ 9004 & 9005 Series, up to 160 cores at 400W
- Memory: Up to 6 TB DDR5 at 6000 MT/s, 24 DIMMs
- Storage: Up to 20 EDSFF drives
- Cooling: Direct Liquid Cooling (DLC) support for power efficiency
- Expansion: PCIe Gen5, up to 2x16 PCIe Gen5 slots, 2 OCP slots; up to 2 GPUs
- Management: HPE iLO 6 + Compute Ops Management
HPE ProLiant DL385 Gen11: AI & Accelerator-Optimized
An accelerator-optimized, dual-socket 2U server built to run AI, ML, and Big Data analytics at enterprise scale.
- Processor: AMD EPYC™ 9004 & 9005 Series, up to 160 cores at 400W, 1152MB L3 cache
- Memory: Up to 6 TB DDR5 at 6000 MT/s, 24 DIMMs
- Storage: EDSFF storage support, hot-plug M.2 RAID boot
- GPU Support: Up to 8x single-wide or 4x double-wide GPUs
- Expansion: PCIe Gen5, up to 2x16 PCIe Gen5 slots, 2 OCP slots
- Management: HPE iLO 6 + Compute Ops Management
HPE ProLiant Compute DL325 Gen12: Next-Level Virtualization
The DL325 Gen12 maximizes rack utilization while mitigating virtualization risks in power-constrained environments, with greater memory capacity than previous generations.
- Processor: AMD EPYC™ 9005 Series, up to 192 cores
- Memory: Up to 6 TB DDR5 at 5200 MT/s
- Storage: Up to 4 LFF, 10 SFF, or 20 EDSFF drives
- GPU Support: Up to 4 single-wide or 2 double-wide GPUs
- Management: HPE iLO 7 + Compute Ops Management
- Security: iLO 7 Secure Enclave + AMD Infinity Guard, FIPS 140-3 Level 3 (in progress), post-quantum ready (NIST CNSA 2.0)
HPE ProLiant Compute DL345 Gen12: Storage-Ready Virtualization
A 2U single-socket server built for storage-dense virtualization, with more memory and storage capacity than the previous generation.
- Processor: AMD EPYC™ 9005 Series, up to 192 cores
- Memory: Up to 6 TB DDR5 at 5200 MT/s
- Storage: Up to 12 LFF, 26 SFF, or 36 EDSFF drives
- GPU Support: Up to 6 single-wide or 4 double-wide GPUs
- Management: HPE iLO 7 + Compute Ops Management
- Security: iLO 7 Secure Enclave + AMD Infinity Guard, FIPS 140-3 Level 3 (in progress), post-quantum ready (NIST CNSA 2.0)
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Built for the Way You Work
HPE ProLiant AMD servers deliver secure, energy-efficient infrastructure for every industry—healthcare, manufacturing, finance, and retail—helping you innovate and grow with confidence.
Deploy confidently at the edge with compact, low-latency HPE ProLiant AMD servers optimized for real-time analytics and distributed workloads.
Featured Server Lineup
Discover high-performance HPE ProLiant servers built with AMD EPYC™ processors.
- 5th Gen AMD EPYC, up to 192 cores
- 1U single-socket, maximizes rack density
- Up to 6 TB DDR5 memory
- 5th Gen AMD EPYC, up to 192 cores
- 2U single-socket, up to 36 EDSFF drives
- Exceptional compute & storage economics
- Compact edge-ready design
- AI & analytics optimized
- Low power, high reliability
- Virtualization powerhouse
- Single-socket efficiency
- Hybrid cloud ready
- Memory-rich for databases
- Efficient for data-heavy apps
- Flexible storage options
- Secure for healthcare & compliance
- Dual-socket scalability
- High availability
- Enterprise-class performance
- Dual-socket versatility
- AI & virtualization ready
Frequently Asked Questions
Find answers to common questions about HPE ProLiant AMD servers, deployment, security, and support.
HPE & AMD $500 Rebate Offer
Buy a qualifying HPE ProLiant AMD server plus a 1-year HPE Morpheus VM Essentials license and get $500 back — or maximize your rebate by adding HPE Zerto Migration Services and benefit from up to $2,550 back.
- Maximum $500 per server, up to $1,500 total per customer.
- HPE Zerto Migration Services: up to $175 per VM (2 VMs per server), up to $1,050 per customer.
- Proof of purchase and delivery required for claim approval.
Qualifying platforms: DL145, DL325, DL345, DL365, DL385, and HPE Morpheus VM Essentials.
Let’s Design Your Ideal Server Solution
Whether you’re optimizing costs, scaling to the edge, or building AI‑ready infrastructure, our specialists will help you choose and customize the perfect AMD-powered HPE ProLiant system for your needs.