HPE ProLiant AMD Servers
HPE ProLiant servers with AMD EPYC™ processors deliver enterprise-grade security, energy-efficient performance, and AI-ready scalability for hybrid and data-intensive workloads.
We get it. IT never sleeps.
Every day, your infrastructure faces new demands. Security threats evolve, workloads expand, and your team is expected to do more with less. Here’s what we hear from IT leaders like you:
Vulnerabilities
From firmware to the cloud, every layer needs protection. One breach can compromise data, trust, and uptime — so defense has to start at the silicon level and extend across your stack.
Visibility gaps
With sprawling hybrid environments, it’s tough to see what’s really happening. Energy use, resource consumption, and system health often live in disconnected dashboards.
Evolving workloads
AI, edge, and virtualization are reshaping compute needs faster than traditional infrastructure can adapt. You need flexibility and performance — without complexity.
Inefficiency
Power costs rise while staff resources shrink. Running at full throttle 24/7 isn’t sustainable for budgets or teams.
We’ll help you modernize without disruption — defend data, simplify management, and free your team to innovate.
Introducing HPE ProLiant Gen12 Servers
The Hybrid-Ready, Energy-Smart Compute Platform
HPE ProLiant Gen12 servers, powered by 5th Gen AMD EPYC™ processors, are engineered for the hybrid world. With up to 192 cores, 6 TB DDR5 memory, and Direct Liquid Cooling (DLC), Gen12 brings breakthrough performance and energy efficiency to AI, edge, and virtualized workloads.
What You Gain with AMD-powered HPE Servers
HPE ProLiant AMD servers deliver energy-efficient compute, robust security, and AI-ready infrastructure for hybrid cloud and data-driven workloads.
Performance & Security Highlights:
5th Gen AMD EPYC processors deliver up to 41% more performance per watt vs. Gen10 systems. Customers achieve up to 68% less power consumption, 87% fewer servers, and 67% lower 3-year TCO for key workloads.
Up to 35% performance gain vs. Gen11 for select workloads. HPE Silicon Root of Trust and AMD Infinity Guard extend multi-layer security from hardware to firmware.
Azure Local Integration
HPE ProLiant AMD EPYC servers are validated and optimized for Microsoft Azure Local. Run Azure-consistent services on-premises, maintain data sovereignty and low latency, and manage hybrid operations easily with Azure Arc and HPE Compute Ops Management (COM).
Deployment Options
Integrated Systems for Azure Local — Turnkey, appliance-like systems with annual OS refreshes and factory integration for seamless setup.
Validated Nodes for Azure Local — Flexible configurations supporting reuse of existing hardware and easy infrastructure integration.
Gen12 Security Highlights
The Gen12 generation introduces HPE iLO 7 with a dedicated Secure Enclave for platform-level protection, AMD Infinity Guard for full-memory encryption, and upcoming FIPS 140-3 Level 3 certification. It’s post-quantum ready with NIST CNSA 2.0 algorithms and features proactive, automated remediation through HPE Compute Ops Management (COM).
- HPE iLO 7 secure enclave for advanced platform protection
- AMD Infinity Guard with expanded memory encryption
- FIPS 140-3 Level 3 compliance (in progress)
- Post-quantum readiness (NIST, CNSA 2.0 algorithms)
- Proactive security and automated remediation via Compute Ops Management (COM)
Core Benefits at a Glance
Up to 41% better performance per watt and 68% lower power use vs. Gen10.
Combines HPE iLO 7, AMD Infinity Guard, FIPS 140-3, and post-quantum readiness.
Accelerates analytics and hybrid workloads with predictive AI energy alerts.
Includes automated carbon reporting and energy forecasting tools.
HPE ProLiant DL145 Gen11: Edge AI-Ready Server
Purpose-built for the edge, the DL145 Gen11 delivers secure, energy-efficient compute for AI, retail, and industrial workloads—wherever you need it most.
- Processor: AMD EPYC™ 8004 Series, 8–64 cores
- Operating Range: –5 °C to 55 °C
- Virtualization: Up to 128 VMs / 480 containers
- Chassis: Wall-mountable 15″×16″, near-silent operation
- GPU: Single or double GPU support, front access
- Management: HPE iLO 6 + Compute Ops Management (COM) for low-touch setup
- Resilience: Dust and shock tolerance for harsh edge environments
| Edge Challenge | DL145 Gen11 Value |
|---|---|
| Extreme temperature & space constraints | Operates –5 °C to 55 °C, compact wall-mount chassis |
| High-density virtualization at the edge | Supports up to 128 VMs / 480 containers |
| AI/ML and GPU acceleration needs | Single/double GPU support, front access |
| Security and supply chain risk | HPE Silicon Root of Trust, iLO 6, AMD Infinity Guard |
| Remote management & automation | GreenLake COM automation, low-touch setup, lower power |
Built for the Way You Work
HPE ProLiant AMD servers deliver secure, energy-efficient infrastructure for every industry—healthcare, manufacturing, finance, and retail—helping you innovate and grow with confidence.
Deploy confidently at the edge with compact, low-latency HPE ProLiant AMD servers optimized for real-time analytics and distributed workloads.
Featured Server Lineup
Discover high-performance HPE ProLiant servers built with AMD EPYC™ processors.
- Compact edge-ready design
- AI & analytics optimized
- Low power, high reliability
- Virtualization powerhouse
- Single-socket efficiency
- Hybrid cloud ready
- Memory-rich for databases
- Efficient for data-heavy apps
- Flexible storage options
- Secure for healthcare & compliance
- Dual-socket scalability
- High availability
- Enterprise-class performance
- Dual-socket versatility
- AI & virtualization ready
Technical Specifications
| Model | Core Range | Max Memory | Memory Speed | Cooling | New Features | Ideal For |
|---|---|---|---|---|---|---|
| DL145 Gen11 | 8–64 | 768 GB | — | Air | Compact edge design | Edge / general workloads |
| DL325 Gen11 | 8–160 (400 W) | 3 TB (1 DPC) | 6400 MT/s | Air | 2DW GPU support | Virtualization, ERM, CRM, digital services |
| DL345 Gen11 | 8–160 (400 W) | 3 TB (1 DPC) | 6400 MT/s | Air | 4SW GPU support | VDI, hybrid cloud, lifecycle & endpoint management |
| DL365 Gen11 | 8–320 (400 W) | 6 TB (1 DPC) | 6400 MT/s | Air | Dual-socket | Compute-intensive |
| DL385 Gen11 | 8–320 (400 W) | 6 TB (1 DPC) | 6400 MT/s | Air | Up to 8 GPU slots | AI / virtualization |
| DL325 Gen12 | 8–192 (up to 500 W) | 6 TB (2 DPC) | 5200 MT/s | DLC | Front I/O, DCMHS | Hybrid cloud / edge |
| DL345 Gen12 | 8–192 (up to 500 W) | 6 TB (2 DPC) | 5200 MT/s | DLC | HPE iLO 7, AI optimization | AI / ML / virtualization |
Based on HPE ProLiant Compute Gen11 and Gen12 AMD EPYC platforms (2024–2025). DLC = Direct Liquid Cooling for superior thermal efficiency in AMD CPU-based servers.
Performance, Efficiency & Sustainability
HPE ProLiant Gen12 systems deliver higher density and lower power consumption than Gen11, thanks to Direct Liquid Cooling (DLC), energy-smart firmware, and adaptive telemetry. Boost performance, cut energy costs, and advance your sustainability goals with HPE iLO 7 UX intelligent management.
Security & Manageability
Security by design — from silicon to software. HPE ProLiant Gen12 integrates AMD Infinity Guard and HPE Silicon Root of Trust to help defend against firmware attacks and supply-chain tampering. New HPE iLO 7 UX streamlines server visibility and management with AI-driven insights.
Learn and Explore
Explore videos and guides to get the most from HPE ProLiant AMD servers—energy-efficient, secure, and AI-ready for your hybrid cloud.
Frequently Asked Questions
Find answers to common questions about HPE ProLiant AMD servers, deployment, security, and support.
Let’s Design Your Ideal Server Solution
Whether you’re optimizing costs, scaling to the edge, or building AI‑ready infrastructure, our specialists will help you choose and customize the perfect AMD-powered HPE ProLiant system for your needs.